4-Chloro-N-(4-tert-butylbenzyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide
- Name 4-Chloro-N-(4-tert-butylbenzyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide
- CAS 119168-77-3
- Purity 99%
Product Details
Factory supply good quality 4-Chloro-N-(4-tert-butylbenzyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide 119168-77-3 with stock
- Molecular Formula: C18H24ClN3O
- Molecular Weight: 333.861
- Vapor Pressure: 5.99E-09mmHg at 25°C
- Melting Point: 61-62oC
- Refractive Index: 1.565
- Boiling Point: 468.4 °C at 760 mmHg
- PKA: 13.19±0.46(Predicted)
- Flash Point: 237.1 °C
- PSA： 46.92000
- Density: 1.13 g/cm3
- LogP: 4.25430
4-Chloro-N-(4-tert-butylbenzyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide(Cas 119168-77-3) Usage
|
Metabolic pathway |
By incubation of tebufenpyrad with rat liver homogenate, tebufenpyrad undergoes biotransformation to yield the major metabolites N-(4- tert-butylbenzyl)-4-chloro-3-(1-hydroxyethyl)-1- methylpyrazole-5-carboxamide via hydroxylation of the w-1-carbon of the ethyl group and N-[4-(1-carboxy-1- methylethyl)benzyl]-4-chloro-3-ethyl-1-methylpyrazole- 5-carboxamide via oxidation of the methyl group in the tert-butyl moiety to the carboxylic acid derivatives.When the rat is orally dosed tebufenpyrad, the major metabolism pathway is via both hydroxylation and oxidation reactions to yield N-[4-(1-carboxy-1- methylethyl)benzyl]-4-chloro-3-(1-hydroxyethyl)-1- methylpyrazole-5-carboxamide which is mainly excreted in the urine. |
InChI:InChI=1/C18H24ClN3O/c1-6-14-15(19)16(22(5)21-14)17(23)20-11-12-7-9-13(10-8-12)18(2,3)4/h7-10H,6,11H2,1-5H3,(H,20,23)
119168-77-3 Relevant articles
Method for preparing pyrazole amide compounds by using microreactor
-
Paragraph 0073-0083, (2020/07/02)
The invention relates to a method for pr...
ACTIVE COMPOUND COMBINATIONS HAVING INSECTICIDAL AND ACARICIDAL PROPERTIES
-
, (2010/08/18)
The novel active compound combinations c...
Synthesis of fully substituted pyrazoles via regio- and chemoselective metalations
Despotopoulou, Christina,Klier, Lydia,Knochel, Paul
supporting information; experimental part, p. 3326 - 3329 (2009/12/01)
The full functionalization of the pyrazo...
Stabilized AGchemical concentrate and use thereof
-
, (2008/06/13)
The present invention relates to the sta...
119168-77-3 Process route
-
-
129560-00-5
1-methyl-3-ethyl-4-chloro-1H-pyrazol-5-ylformylic acid chloride
-
-
39895-55-1
4-(1,1-dimethylethyl)-benzenemethanamine
-
-
119168-77-3
tebufenpyrad
| Conditions | Yield |
|---|---|
|
In
toluene;
at 50 ℃;
for 0.138889h;
Time;
Temperature;
|
95.8%
|
-
-
4-chloro-5-ethyl-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester
-
-
39895-55-1
4-(1,1-dimethylethyl)-benzenemethanamine
-
-
119168-77-3
tebufenpyrad
| Conditions | Yield |
|---|---|
|
4-(1,1-dimethylethyl)-benzenemethanamine;
With
sodium hydride;
In
tetrahydrofuran;
Inert atmosphere;
4-chloro-5-ethyl-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester;
In
tetrahydrofuran;
at 25 ℃;
for 3h;
Inert atmosphere;
|
75%
|
119168-77-3 Upstream products
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39895-55-1
4-(1,1-dimethylethyl)-benzenemethanamine
-
129560-00-5
1-methyl-3-ethyl-4-chloro-1H-pyrazol-5-ylformylic acid chloride
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