2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate
- Name 2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate
- CAS 122111-11-9
- Purity 99%
Product Details
Top quality factory supply 122111-11-9 2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate at low price
- Molecular Formula: C20H18F2O8S
- Molecular Weight: 456.421
- Appearance/Colour: Brown liquid
- Vapor Pressure: 2.41E-11mmHg at 25°C
- Refractive Index: 1.652
- Boiling Point: 588.439 °C at 760 mmHg
- Flash Point: 309.677 °C
- PSA： 113.58000
- Density: 1.464 g/cm3
- LogP: 3.48620
2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate(Cas 122111-11-9) Usage
InChI:InChI=1/C9H11F2N3O4/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17)/t4-,6-,7-/m0/s1
122111-11-9 Relevant articles
High-selectivity synthesis method for gemcitabine intermediate
-
Paragraph 0061-0062, (2021/01/29)
The invention discloses a high-selectivi...
Purification method of gemcitabine intermediate
-
Paragraph 0079; 0083-0084, (2021/06/22)
The invention provides a purification me...
Azido nucleosides and nucleotide analogs
-
Page/Page column 112-114, (2016/06/13)
Disclosed herein are 4′-azido-substitute...
SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF
-
Paragraph 0866; 0867, (2013/07/05)
Disclosed herein are nucleosides, nucleo...
122111-11-9 Process route
-
-
153012-08-9
C19 H16 F2 O6
-
-
124-63-0
methanesulfonyl chloride
-
-
134877-42-2,134877-43-3,122111-11-9
3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-D-erythro-pentofuranose
| Conditions | Yield |
|---|---|
|
With
triethylamine;
In
dichloromethane;
at 0 ℃;
for 2h;
|
97.8%
|
-
-
124-63-0
methanesulfonyl chloride
-
-
1173824-58-2,143157-25-9,143157-22-6
(2R,3R)-2-((benzoyloxy)methyl)-4,4-difluoro-5-hydroxyoxolan-3-yl benzoate
-
-
134877-42-2,134877-43-3,122111-11-9
3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-D-erythro-pentofuranose
| Conditions | Yield |
|---|---|
|
With
triethylamine;
In
dichloromethane;
at 23 ℃;
for 2h;
|
100%
|
|
With
triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 18h;
Inert atmosphere;
|
100%
|
|
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 2h;
|
95%
|
|
With
triethylamine;
at 0 - 20 ℃;
for 3h;
Cooling with ice;
|
63%
|
|
(2R,3R)-2-((benzoyloxy)methyl)-4,4-difluoro-5-hydroxyoxolan-3-yl benzoate;
With
triethylamine;
In
dichloromethane;
at 0 ℃;
for 0.5h;
methanesulfonyl chloride;
In
dichloromethane;
at 0 - 25 ℃;
for 12 - 14h;
|
|
|
With
triethylamine;
In
dichloromethane;
at 0 - 5 ℃;
for 1.5h;
Product distribution / selectivity;
|
|
|
With
triethylamine;
In
dichloromethane;
at 0 - 5 ℃;
for 1.5h;
Product distribution / selectivity;
|
|
|
With
triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 2h;
|
113.4 g
|
|
With
triethylamine;
In
tetrahydrofuran; dichloromethane;
at 0 - 20 ℃;
for 2h;
|
|
|
With
triethylamine;
In
toluene;
for 6h;
Reflux;
Large scale;
|
2.5 kg
|
122111-11-9 Upstream products
-
124-63-0
methanesulfonyl chloride
-
1173824-58-2
(2R,3R)-2-((benzoyloxy)methyl)-4,4-difluoro-5-hydroxyoxolan-3-yl benzoate
-
122111-01-7
2-deoxy-2,2-difluoro-D-erythro-pentonic acid γ-lactone 3,5-dibenzoate
-
928797-50-6
ethyl (3R,S)-2,2-difluoro-3-hydroxy-(2,2-dimethyldioxolpent-4-yl)propionate
122111-11-9 Downstream products
-
143157-23-7
1-(2'-deoxy-2',2'-difluoro-3',5'-di-O-benzoyl-D-ribofuranosyl)-4-acetamidopyrimidin-2-one
-
134790-40-2
C23 H19 F2 N3 O6
-
134790-39-9
(2'-deoxy-2',2'-difluorocytidine)-3',5'-dibenzoate
-
103882-84-4
2’-deoxy-2’,2’-difluoro-cytidine
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