4-Chlorophenylacetone
- Name 4-Chlorophenylacetone
- CAS 5586-88-9
- Purity 99%
Product Details
High Quality Chinese Manufacturer supply 5586-88-9 4-Chlorophenylacetone
- Molecular Formula: C9H9ClO
- Molecular Weight: 168.623
- Appearance/Colour: Clear light yellow liquid
- Vapor Pressure: 0.0471mmHg at 25°C
- Melting Point: 6-8 °C
- Refractive Index: 1.5325-1.5345
- Boiling Point: 236.5 °C at 760 mmHg
- Flash Point: 116.3 °C
- PSA： 17.07000
- Density: 1.14 g/cm3
- LogP: 2.47150
4-Chlorophenylacetone(Cas 5586-88-9) Usage
|
Preparation |
At present, there are three main synthetic routes for 4-chlorophenylacetone. The first is to synthesize 4-chlorophenylacetone with sodium p-chlorobenzenesulfonate and acetone as raw materials, with a yield of about 54%. The second synthesis route is to synthesize 4-chlorophenylacetone with p-chlorobenzenesulfonyl chloride and chloroacetone as raw materials. The third synthesis route is to synthesize 4-chlorophenylacetone from chloroacetone. |
|
Synthesis Reference(s) |
The Journal of Organic Chemistry, 48, p. 2590, 1983 DOI: 10.1021/jo00163a034 |
|
Health Hazard |
When it contacts with skin and mucous membrane, 4-chlorophenylacetone will cause inflammation, so pay attention to safety when using 4-chlorophenylacetone. This chemical is harmful to environment. It should be prevented from contacting groundwater, waterways or sewage systems. Without government permission, 4-chlorophenylacetone should not be discharged into the surrounding environment. |
InChI:InChI=1/C9H9ClO/c1-7(11)6-8-2-4-9(10)5-3-8/h2-5H,6H2,1H3
5586-88-9 Relevant articles
Asymmetric Catalytic Epoxidation of Terminal Enones for the Synthesis of Triazole Antifungal Agents
Feng, Xiaoming,He, Qianwen,Liu, Xiaohua,Zhang, Dong,Zhang, Fengcai
supporting information, p. 6961 - 6966 (2021/09/11)
An enantioselective epoxidation of α-sub...
Aryl C-F bond functionalization preparation method
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Paragraph 0052; 0089-0093; 0117-0121, (2021/09/29)
The invention relates to the technical f...
Gold-Catalyzed [3+2]-Annulations of α-Aryl Diazoketones with the Tetrasubstituted Alkenes of Cyclopentadienes: High Stereoselectivity and Enantioselectivity
Chen, Ching-Nung,Cheng, Wei-Min,Wang, Jian-Kai,Chao, Tzu-Hsuan,Cheng, Mu-Jeng,Liu, Rai-Shung
supporting information, p. 4479 - 4484 (2021/01/21)
This work reports gold-catalyzed [3+2]-a...
Iron powder and tin/tin chloride as new reducing agents of Meerwein arylation reaction with unexpected recycling to anilines
Abdelwahab, Ahmed B.,El-Sawy, Eslam R.,Kirsch, Gilbert
supporting information, p. 526 - 538 (2020/01/08)
Simple and rapid route for Meerwein aryl...
5586-88-9 Process route
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-
108-24-7
acetic anhydride
-
-
104-83-6
1-Chloro-4-(chloromethyl)benzene
-
-
5406-33-7
4-chlorobenzyl acetate
-
-
138376-43-9
(E)-1-(4-chlorophenyl)prop-1-en-2-yl acetate
-
-
5586-88-9
1-(4-chlorophenyl)propan-2-one
| Conditions | Yield |
|---|---|
|
With
tetraethylammonium tosylate;
In
N,N-dimethyl-formamide;
Ambient temperature;
electroreduction: Pb-cathode, carbon-rod anode, 15mA/cm-2;
|
7%
8% 56% |
-
-
108-22-5
Isopropenyl acetate
-
-
106-47-8
4-chloro-aniline
-
-
5586-88-9
1-(4-chlorophenyl)propan-2-one
| Conditions | Yield |
|---|---|
|
With
ethyl nitrite; potassium carbonate;
In
acetone;
at 0 - 20 ℃;
for 3.5h;
|
80.2%
|
|
With
tert.-butylnitrite; water; salicylic acid;
In
acetonitrile;
at 20 ℃;
for 3h;
Inert atmosphere;
Schlenk technique;
|
62%
|
|
With
hydrogenchloride; tin; tin(ll) chloride; sodium nitrite;
In
water; N,N-dimethyl-formamide; acetone;
at 0 - 20 ℃;
Reagent/catalyst;
|
51%
|
|
Multistep reaction;
(i) NaNO2, aq. acid, (ii) /BRN= 1280347/, CuCl, acetone;
|
|
|
4-chloro-aniline;
With
tetrafluoroboric acid; sodium nitrite;
In
water;
at 0 ℃;
for 0.666667h;
Isopropenyl acetate;
With
tris(2,2'-bipyridyl)ruthenium dichloride;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 2h;
Irradiation;
|
31 mg
|
|
4-chloro-aniline;
With
boron trifluoride diethyl etherate;
In
dichloromethane;
at -20 ℃;
for 0.333333h;
With
tert.-butylnitrite;
In
dichloromethane;
at -15 - 0 ℃;
for 0.5h;
Isopropenyl acetate;
With
copper(I) oxide; sodium acetate;
In
dichloromethane;
at 20 ℃;
for 12h;
|
1.10 g
|
|
4-chloro-aniline;
With
hydrogenchloride; sodium nitrite;
In
water;
at 0 ℃;
for 0.5h;
With
tetrafluoroboric acid;
In
water;
at 0 ℃;
for 3h;
Isopropenyl acetate;
With
copper(I) oxide; sodium methylate;
In
water;
at 35 - 40 ℃;
for 8h;
|
|
|
4-chloro-aniline;
With
hydrogenchloride; sodium nitrite;
In
water;
at 0 ℃;
for 0.666667h;
With
tetrafluoroboric acid;
In
water;
at 0 ℃;
for 0.5h;
Isopropenyl acetate;
With
copper(I) oxide; sodium acetate;
at 20 ℃;
|
5586-88-9 Upstream products
-
1878-66-6
4-chlorophenylacetic Acid
-
108-24-7
acetic anhydride
-
78-95-5
chloroacetone
-
108-90-7
chlorobenzene
5586-88-9 Downstream products
-
64-12-0
p-Chloroamphetamine
-
16236-49-0
(4-chloro-phenyl)-acetone semicarbazone
-
53219-82-2
3-(4-chloro-benzyl)-5-furan-3-yl-1-phenyl-4,5-dihydro-1H -pyrazole
-
2004-22-0
6β-[(Ξ)-2-(4-chloro-phenyl)-1-methyl-ethylamino]-penicillanic acid
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